Graduating from Vanderbilt University in 2020, Saben Lee signed his first professional contract with the Detroit Pistons of the NBA on a two-year deal. In the 2021-22 season, he also played for the G-League team Motor City Cruise and in the 2022-23 season he signed with another NBA team, the Philadelphia 76ers. That same season, he appeared for the G-League team Delaware Blue Coats and in December 2022 he headed to Canada to join another G-League team, Raptors 905 Mississauga. In January 2023, he returned to the United States to join the Phoenix Suns in the NBA. After spending two seasons there, Lee made his first overseas transfer to Turkey, signing with Manisa Basket of the Türkiye Sigorta Basketball Super League. During the season, he moved to Israel’s Maccabi Tel Aviv before returning once again to Manisa. In February 2025, he joined Olympiacos in Greece.

Saben Lee earned Second Team All-SEC honors in the NCAA during the 2019-20 season. In the 2021-22 season, he averaged 28,5 points per game, ranking first in this category in the G-League. Last season, he celebrated both the Greek League Championship and the Greek Cup title with Olympiacos.

This season in the Greek League, Lee played in 10 games, averaging 18:20 minutes, with 10,2 points, 1,7 rebounds and 2,9 assists per game.

In the EuroLeague, the American guard appeared in 11 games, averaging 11:24 minutes, with 3,4 points, 0,4 rebounds and 1,4 assists per game.